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Het is nogal een lang artikel omdat vit D synthese etc een subonderwerp is. Dus ik heb er even een stuk uitgeknipt wat specifiek gaat over K2 de rol daarvan in calcium build up in het lichaam;
Oral supplementation of D3 is the easiest means to prevent deficiencies. A frequent argument against supplementation of vitamin D3 is that an increased intake could lead to a vitamin D toxicity, also called hypervitaminosis D (Orme et al., 2016). This again can cause hypercalcemia, which is the buildup of calcium in the blood leading to vascular calcification, osteoporosis, and kidney stones. However, it has been reported that the reason for hypercalcemia rather lays in a vitamin K2 deficiency (Flore et al., 2013, Vermeer and Theuwissen, 2011), as K2 activates the bone gamma-carboxyglutamic acid-containing protein (osteocalcin) through carboxylation. Activated osteocalcin deposits calcium in the bones, whereas non-activated osteocalcin inhibits calcium absorption by the bones. As the osteocalcin synthesis rate is increased by higher 25(OH)D serum levels, K2 is required as a natural antagonist (Yasui et al., 2006, Dofferhoff et al., 2020).
Dit is de link naar het artikel;
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7406600/
In het artikel zelf zijn alle tussen haakjes staande onderzoeken gelinked dus kan kun je ze aan klikken en verder lezen.
